Young researcher Cheng Wei from the Institute of Brain-inspired Intelligence Science and Technology at Fudan University came to the school to give a report

Reporter: Cheng Wei, Young Researcher, Institute of Brain-inspired Intelligence Science and Technology, Fudan University

Report topic: Research on schizophrenia based on neuroimaging big data

Time: June 7, 2023 (Wednesday) 16:00-17:30

Location: Conference Room A106, Information Technology Building (offline)

Tencent conference number: 129-117-012 (online)

Host: Wan Zhuo, Nanjing University of Information Science & Technology

Report summary: Schizophrenia is a serious mental illness. The development of neuroimaging big data provides new opportunities for precise diagnosis and treatment of schizophrenia. The speaker will introduce his team’s research results on neuroimaging biomarkers of schizophrenia in recent years. First, based on functional imaging data, develop a new whole-brain correlation analysis method to identify abnormal neural circuits in schizophrenia at the voxel level; further address the problem of high heterogeneity in schizophrenia, use data-driven disease progression models and large-scale imaging data to discover two biological subtypes of schizophrenia, whose brain atrophy originates from the hippocampus and language area respectively, and the two have different treatment effects; finally, use “epicenter mapping” (epicenter mapping) mapping) method to construct a new imaging index for schizophrenia, verify the index’s cross-disease sensitivity and predictive value for treatment, and combine multi-modal data to elucidate the molecular genetic mechanism behind it.

Brief introduction of the speaker: Cheng Wei is a young researcher at the Institute of Brain-inspired Intelligence Science and Technology of Fudan University, a dual-employed PI at Huashan Hospital affiliated to Fudan University, and an honorary researcher at the University of Warwick in the UK. The research field is the development of imaging genetic big data statistical methods and their application in neuropsychiatric diseases to achieve early clinical diagnosis and precise treatment. Selected as a national-level young talent, Shanghai Morning Star Talent Program, and presided over projects such as the National Natural Science Foundation of China and the Shanghai Natural Science Foundation. He has published more than 40 papers as the corresponding or first author (including co-author), including JAMA Psychiatry, NatureAging.NatureMental Health, Brain, etc., and his research results have been successfully applied to the clinical treatment of depression. He serves on the editorial board of Journal of NeuroscienceMethods and as a reviewer for several journals such as Nature Human Behavior and Biological Psychiatry.

Translated from the original Chinese source.